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SX-fraction, an active component of SX-Fraction®, is a glycoprotein
with molecular weight about 20,000 Dalton
extracted from Maitake mushroom through proprietary process developed by MPI.
According to the studies conducted by Georgetown University, SX-fraction
reduced the levels of FBG (fasting blood glucose), blood pressure, TG
(Triglyceride) and body weight in ZFR (Zucker Fatty
Rats: genetically obese and diabetic rats), and also prevented formation of
insulin resistance in SHR (Spontaneous Hypertensive Rats: hypertension rats)
raised with sugar rich diet(1-3).
As they are animal models of human diabetes and
metabolic syndrome, a preliminary clinical study was conducted in Japan with 19 patients
with Type 2 diabetes. As expected, administration of SX-Fraction® (9 tablets per day)
for 2 months has reduced FBG, TG, insulin and body weight significantly(4).
Since PCOS (Polycystic Ovary Syndrome) is considered to
be caused by insulin resistance, MPI and Dr. Kunihiko
Tominaga of Loma Linda Clinic, Japan, have
conducted a clinical study to evaluate effectiveness of SX-Fraction® on PCOS as
follows.
Twelve PCOS patients with no menstruation for more than 3
months were recruited. After taking informed consent, patients were randomly
assigned to treatments by either SX-Fraction® (9 tablets per day) or Shakuyaku-kanzo-to (SKT), a traditional Chinese formula
frequently used for PCOS by Japanese gynecologists, for 6 months. Basic Body
Temperature was recorded every morning to judge ovulation. In the end of the
trial ovulation was observed in 17 menstrual cycles out of 36 cycles (47.2%) in
SX-Fraction®
patients, and 8 cycles out of 36 cycles (22.2%) in SKT patients (p<0.05).
The difference was noted as early as in 3 months, as ovulation was observed in
10/18 cycles (55.5%) in SX-Fraction® and in 3/18 cycles (16.6%) in SKT
(p<0.05)(5).
The result strongly suggests that SX-Fraction® may help
normalization of menstruation and ovulation in PCOS patients, and that SX-Fraction®
may actually help improve insulin resistance, which attracts skyrocketing
attention of medical professionals for its strong association with various
serious diseases such as diabetes, metabolic syndrome, cancer, Alzheimerfs
disease and overall aging.
(1) Talpur N., Echard B., Dadgar A., Aggarwal S., Zhuang C., Bagchi D.
and Preuss H.G.: Research Communication in Molecular Pathology and
Pharmacology, 112, 68-82 (2002) (Actually published as of March 9th, 2004)
(2) Talpur N., Echard
B.W., Yasmin T., Bagchi D.
and Preuss H.G.: Molecular and Cellular Biochemistry, 252, 369-377 (2003)
(3) Preuss H.G.: Exhaustive Study on Functional Materials for Metabolic
Syndrome and Anti-Aging, Japan Health Expo 2006 , March 22, Tokyo (2006)
(4) Anzai, H.: Food Style 21, 10(3), 25-28 (2006)
(5) Tominaga, K.:@Journal of Traditional Medicines, 22, Sup.2,
188 (2005)
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